FTY720-derivatives do not induce FTY720-like lymphopenia
نویسندگان
چکیده
منابع مشابه
Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.
FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) is an orally available immunomodulatory agent that induces severe peripheral blood lymphopenia. Most studies of these lymphopenic effects have been limited to short-term exposure to FTY720. FTY720 alters the ability of lymphocytes to respond to sphingosine-1-phosphate (S1P) through S1P receptors, particularly S1P1. FTY720...
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FTY720 (Fingolimod) is known to have a significant therapeutic effect on experimental autoimmune encephalomyelitis (EAE). Here, we used an EAE mouse model, which had been established by immunizing C57BL/6J mice with a partial peptide of myelin oligodendrocyte glycoprotein (MOG₃₅₋₅₅), to examine the relapse of EAE upon discontinuation of treatment with FTY720 alone or in combination with MOG₃₅₋₅...
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FTY720, a potent immunomodulatory drug in phase 2/3 clinical trials, induces rapid and reversible sequestration of lymphocytes into secondary lymphoid organs, thereby preventing their migration to sites of inflammation. As prerequisite for its function, phosphorylation of FTY720 to yield a potent agonist of the sphingosine-1-phosphate receptor S1P(1) is required in vivo, catalyzed by an as-yet-...
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2-Amino-2-[2-(4-octylphenyl)]-1,3-propanediol hydrochloride (FTY720) is a potent immunosuppressant which has been approved by the Food and Drug Administration (FDA) as a new treatment for multiple sclerosis. As an immunosuppressant, it displays its anti-multiple sclerosis, immunosuppressive effects by activating sphingosine-1-phosphate receptors (S1PRs). In addition to the immunosuppressive eff...
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IN CONTRAST TO the subfamily of neutrophil and mononuclear chemotactic cytokines (chemokines) upregulated by inflammation, FTY720 seems to affect the interactions of lymphocytes with the subfamily of homing chemokines, secondary lymphoid tissue chemokine (SLC) and essential myosin light chain chemokine (ELC). These homing chemokines are constitutively expressed in T-cell zones of secondary lymp...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2017
ISSN: 1347-8613
DOI: 10.1016/j.jphs.2017.02.006